What are the possible implications of either biological responses on clinical tumor (melanoma) outcomes if PBM therapy is combined with current cancer treatments?

The PBM paper outlines the evidence for two major anti-tumor responses – vasculature normalization and increased immune cell infiltration. What are the possible implications of either biological responses on clinical tumor (melanoma) outcomes if PBM therapy is combined with current cancer treatments?

Design a study (3-5 sentences each) to confirm individual possibilities.