Synthesis and Characterizations of Platinum (II) complex drug, PhenSS

Synthesis and Characterizations of Platinum (II) complex drug, PhenSS

Project Details

Paper Topic : Final Report

Style : APA

Language Style : English (U.K.)

Type of Assignment : Article

Acedemic Level : Undergraduate Level

Number of Sources : 15

Order Instructions

files will be attached – Writer will have to make sure to read and follow marking criteria
hi the reference style should be harvard or Vancouver style. its not APA style. also when you will give me the assignment i need to send it to the teacher and she will tell me what to change if i need that and then i will send it to you back to change the things if the teacher required that.
these are the learning guide and the marking criteria for the report and all the information that related to the report. so please read it carefully
the prac notes which i used to do the experiment but i used a drug called PhenSS not 56MESS. two examples, one example is same as my topic and the other one is different from my topic.

the excel results that you are going to use it for the discussion and the results part.
nmr results. I did carbon nmr, 1H nmr and pt nmr. please write a discussion about the nmr results.       Filename 1 : PhenSS_ nmrC_3_.pdf Filename 2 : PhenSS_ nmrH_3_.pdf Filename 3 : PhenSS_ nmrPt_3_.pdf

you can use this risk assessment to know the chemicals that we used for the experiment.       Filename 1 : Risk assessmant.docx

the literature review that you did before with the teacher comment. please read the comments and see the mistake that you did in the review.
two examples, one example is same as my topic and the other one is different from my topic.


Answer preview:

A chemotherapeutic platinum-based drug with anticancer potency has been designed and synthesized at the University of Western Sydney. The platinum-based drug [(1,10-phenthanroline)(1S,2S-diaminocycohexane) platinum(II)] dichloride (PhenSS) was prepared by a reaction between K2PtCl4 and 1S,2S-diaminocyclohexane, and refrigerated for 7 days to produce [Pt(SS-dach)Cl2]. the resulting solid was refluxed with 1,10-phenthanroline for 2 days to produce [Pt(phen)(SS-dach)]Cl2. Successful synthesis was confirmed by Nuclear Magnetic Resonance (NMR) and Ultraviolet radiation (UV). The complex was characterised using 1H, 13C and 195Pt NMR which were in close agreement to spectra reported in the literature.One of the greatest success stories in the medicinal inorganic chemistry field is represented in the platinum anticancer agents that exist today. The World Health Organization (WHO, 2013) lists some of the drugs produced using platinum and other metals in its list of essential drugs. Although the drugs were discovered close to half a century ago, they are as efficient as they were during the days of launching them. WHO (2013) list of essential medicines has listed carboplatin cisplatin and oxaliplatin as medicines efficient in treating cancers

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