Explain the causative factors and pathophysiology of Cushing syndrome
Sara Haines Cushing syndrome case study
Sara Hainesis a 38-year-old whoruns Grand Central Restaurant at Toowoomba shopping centre. She presented to St Vincent's Private Hospital, Toowoomba complaining of drastic weight gain over six months, significant facial hair growth, menstrual abnormalities, and both excessive thirst and appetite. Recently, Sara also feels dull and depressed, does not have much energy, and has stopped performing all her favouriteactivities including tennis at Action Indoor Sports Stadium.
Sara is a successful and busy businessperson in Toowoomba, never smoked and only consumes alcohol in moderation at social events. She has several allergies (House dust mites, cockroaches, and dog’s dander) and is not taking any medications other than a daily multivitamin tablet and betamethasone (as needed) for her asthma (used for many years). On clinical examination, the clinician, Dr John Smith noticed protuberant with striae and minimal bruising in her abdomen, and no abdominal tenderness, and both upper and lower extremities show areas of hyperpigmentation. Laboratory results confirmed that her cortisol levels were high indicating Cushing syndrome.
Answer only TWO questions
1. Explain the causative factors and pathophysiology of Cushing syndrome and how she developed this condition.
2. Describe the primary signs and symptoms of Cushing syndrome.
3. What aspects of her clinical history place Sara at increased risk of hypertension and,brieflyexplainthe difference between Graves’ disease and Cushingsyndrome.
4. What treatment and follow up options are there for her condition?